By integrating observational analysis with sibling comparisons and Mendelian randomization, the cross-continental study isolates loneliness as an independent driver of systemic health decline and multi-condition physical frailty, establishing personal emotional disconnection as a high-priority public health emergency demanding integrated policy intervention.
By integrating observational analysis with sibling comparisons and Mendelian randomization, the cross-continental study isolates loneliness as an independent driver of systemic health decline and multi-condition physical frailty, establishing personal emotional disconnection as a high-priority public health emergency demanding integrated policy intervention.
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